Anti-Stress

Metabolic Effects of Dark Chocolate Consumption on Energy, Gut Microbiota, and Stress-Related Metabolism in Free-Living Subjects

Francois-Pierre J. Martin, Serge Rezzi, Emma Per-Trepat, Beate Kamlage, Sebastiano Collino, Edgar Leibold, Jrgen Kastler, Dietrich Rein, Laurent B. Fay and Sunil Kochhar.

Nestle Research Center, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland, Metanomics GmbH, Tegeler Weg 33, 10589 Berlin, Germany, BASF SE, 67056 Ludwigshafen, Germany, and Metanomics Health GmbH, Tegeler Weg 33, 10589 Berlin, Germany

Publication Date (Web): October 7, 2009

Dietary preferences influence basal human metabolism and gut microbiome activity that in turn may have long-term health consequences. The present study reports the metabolic responses of free living subjects to a daily consumption of 40 g of dark chocolate for up to 14 days. A clinical trial was performed on a population of 30 human subjects, who were classified in low and high anxiety traits using validated psychological questionnaires. Biological fluids (urine and blood plasma) were collected during 3 test days at the beginning, midtime and at the end of a 2 week study. NMR and MS-based metabonomics were employed to study global changes in metabolism due to the chocolate consumption. Human subjects with higher anxiety trait showed a distinct metabolic profile indicative of a different energy homeostasis (lactate, citrate, succinate, trans-aconitate, urea, proline), hormonal metabolism (adrenaline, DOPA, 3-methoxy-tyrosine) and gut microbial activity (methylamines, p-cresol sulfate, hippurate). Dark chocolate reduced the urinary excretion of the stress hormone cortisol and catecholamines and partially normalized stress-related differences in energy metabolism (glycine, citrate, trans-aconitate, proline, β-alanine) and gut microbial activities (hippurate and p-cresol sulfate). The study provides strong evidence that a daily consumption of 40 g of dark chocolate during a period of 2 weeks is sufficient to modify the metabolism of free living and healthy human subjects, as per variation of both host and gut microbial metabolism.

http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/pr900607v?

Category: Mental, Emotional & Spiritual Effects
Posted: Sunday, February 14, 2010 06:13:00 PM
Views: 4151
Synopsis: Learn about Theobroma Cacao / Chocolate's stress lowering characteristics.